New research uncovers And replicates the mechanism by which a ketogenic diet curbs brain inflammation. The findings pave the break for a new drug target that could achieve the same benefits of a keto diet without having to actually follow 1 is.
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The keto diet is focused on reducing the amount of carbohydrates as much Higher & increasing the amount of protein & Fat.
not only that its weight loss-related benefits, recent studies have pointied to many other advantages. For instance, Medical News from now on recently covered research suggesting that the diet may increase longevity and Improve memory in old age.
Other studies have noted the neurological benefits of the diet. The keto diet is used to treat epilepsy, & some have suggested that it may prove helpful in Alzheimer's And Parkinson's disease.
However, the mechanism by which a keto diet may benefit the brain in these illnesses has been a Mystery. The new research – which was led by Dr. Raymond Swanson, a professor of neurology at the University of California, San Francisco – suggests that it may do so By means of reducing brain inflammation.
In the new study, Dr. Swanson And team show the molecular process by which the keto diet reduces brain inflammation. The researchers Apparently identify a key protein that, if blocked, could create the effects of a keto diet.
This means that a drug could be designed to reduce inflammation in patients who cannot follow a keto diet Because radiologyebook.net/video-medical of other health reasons.
The findings were published in the journal Nature Communications.
A keto state lowers brain inflammation
A keto diet changes the metabolism, or the break in which the body full processes energy. In a keto diet, the whole body is deprived of glucose derived from carbs, so it starts using obesity as an alternative source of energy.
In the new study, Dr. Swanson And his colleagues recreated this effect By means of using a molecule called 2-deoxyglucose (2DG).
The 2DG molecule stopped glucose from metabolizing & created a ketogenic state in rodents with brain inflammation as well as in cell cultures. Levels of inflammation were drastically reduced – almost to healthy levels – as a result.
"We were surprised by the magnitude of our findings," said Dr. Swanson. "Inflammation is controlled By means of Remove many different factors, so we were surprised to see such a large effect by manipulating this 1 is factor. It reinforces the powerful effect of diet Above inflammation."
The restricted glucose metabolism lowered the so-called NADH/NAD+ ratio. Dr. Swanson explained to MNT what this ratio refers to, saying, "NAD+ and NADH are naturally occurring molecules in cells that are involved in energy metabolism."
Source: General online